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Manasa, K.
- A Review on Transbuccal Drug Delivery System and its Commercially Available Products
Abstract Views :497 |
PDF Views:0
Authors
Affiliations
1 Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, IN
1 Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, IN
Source
Research Journal of Pharmacy and Technology, Vol 6, No 1 (2013), Pagination: 22-28Abstract
Buccal route is one of the promising area where continuous research is going on in order to increase the bioavailability of most of the drugs effected by first pass metabolism and also to increase possibility of oral delivery of protein and peptide drugs with high patient compliance. In order to achieve the required target of bioavailability, drugs are formulated in different buccal dosage forms. The objective of this article is to enlighten the commercial products of various buccal dosage forms and their evaluation.Keywords
Buccal Route, First Pass Metabolism, Bioavailability, Oral Mucosa, Marketed Products
References
- Buccal drug delivery system in N.K. Jain: Advances in controlled and novel drug delivery system 1 st ed: pp 78-80
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- Spiegeleer BD et al. Dissolution stability and IVIVC investigation of a buccal tablet. Anal Chim Acta. 2001; 446: 345- 351
- Kerec M. et al. Mucoadhesion on pig vesical mucosa: Influence of polycarbophil/calcium interactions. Int J Pharm. 2002; 241: 135-143.
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- . Kusum Devi V et al., Design and Evaluation of Matrix diffusion Controlled Transdermal patches of Verapamil Hydrochloride, Drug Dev Ind Pharm 2003; 29(5):495-503.
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- Siddiqui MN, Garg G, Sharma PK, Fast dissolving tablets: Preparation, characterization and evaluation: An overview, International Journal of Pharmaceutical Sciences Review and Research, 2010, 4 (2).
- Felton L., P. O'Donnell and J. McGinity, Mechanical dispersions, in: Aqueous polymeric coatings pharmaceutical dosage forms, 3rd edition, J. Mc Ginity, L. Felton (Eds), Vol. 176, Drugs and the electronic tongue to optimize taste masking in a Pharmaceutical Sci., pp: 108.
- Development and Validation of Visible Spectrophotometric Method for Determination of Andrographolide in Kalmegh Plant Extract
Abstract Views :198 |
PDF Views:1
Authors
A. Suneetha
1,
K. Manasa
1
Affiliations
1 Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Guntur, A.P - 522002, IN
1 Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Guntur, A.P - 522002, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 4, No 2 (2014), Pagination: 85-88Abstract
A simple, sensitive, precise and accurate UV Spectrophotometric method has been developed for estimation of andrographolide in kalmegh plant extract. The method is based on the formation of red-orange colored complex with picric acid in an alkaline medium and obeys beer's law in the range of 10 - 100μg/mL exhibiting the maximum absorbance at 481nm. The limit of detection and quantification were found to be 1.0μg/mL and 3.0μg/mL, respectively. The calibration curve demonstrated a linear relationship between the absorbance and concentration, with the correlation coefficient 0.9998. The Regression equation of the curve was Y=0.0114x + 0.0067. The method was validated according to ICH guidelines.Keywords
Andrographolide, Picric Acid, NaOH, Validation, ICH Guidelines.- Importance of Soil Health Card to Sustain the Living Dynamic System
Abstract Views :148 |
PDF Views:1
Authors
Affiliations
1 Department of Soil Science and Agricultural Chemistry, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
2 Department of Soil Science and Agricultural Chemistry, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN
3 Department of Agricultural Microbiology and Bioenergy, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
1 Department of Soil Science and Agricultural Chemistry, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
2 Department of Soil Science and Agricultural Chemistry, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN
3 Department of Agricultural Microbiology and Bioenergy, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
Source
An Asian Journal of Soil Science, Vol 12, No 1 (2017), Pagination: 217-220Abstract
It is a Government of India's scheme promoted by the Department of Agriculture and Co-operation under the Ministry of Agriculture. It will be implemented through the Department of Agriculture of all the State and Union Territory Governments. A SHC is meant to give each farmer soil nutrient status of his holding and advice him on the dosage of fertilizers and also the needed soil amendments, that he should apply to maintain soil health in the long run.Keywords
Soil Health Card, Sustain, Living Dynamic System.References
- “1.12 crore soil health cards distributed so far”, The Hindu Business Line, 25 February 2016.
- Parsai, Gargi (2015). Soil health card scheme takes off gingerly, The Hindu.
- Sood, Jyotika (2015). Unearthing the loopholes in Modi government’s Soil Health Card scheme, Daily News and Analysis, Mumbai (M.S.) INDIA.
- “States Governments have distributed 1.12 crore soil health cards”, The Economic Times, 25 February 2016.
- P.M. Narendra Modi launches (2015). Soil health card’ scheme for farmers in Rajasthan, zeenews.india.com, retrieved 2015-03-07.
- Polymer Coated Fertilizers as Advance Technique in Nutrient Management
Abstract Views :143 |
PDF Views:1
Authors
Affiliations
1 Department of Soil Science and Agricultural Chemistry, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
2 Department of Soil Science and Agricultural Chemistry, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN
3 Department of Agricultural Microbiology and Bioenergy, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
1 Department of Soil Science and Agricultural Chemistry, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
2 Department of Soil Science and Agricultural Chemistry, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani (M.S.), IN
3 Department of Agricultural Microbiology and Bioenergy, College of Agriculture, Prof. Jayashankar Telangana State Agricultural University, Rajendranagar, Hyderabad (Telangana), IN
Source
An Asian Journal of Soil Science, Vol 12, No 1 (2017), Pagination: 228-232Abstract
Control release fertilizers (CRF's) are coated fertilizers that release nutrients over an extended period of time at a rate driven primarily by temperature and moisture of the ischolar_main zone. Polymer coated fertilizers (PCF's) were also a type of CRF's, which are solid or other nutrient core, coated with various polymers ("plastics"). Fertilizer use efficiency can be increased by application of polymer coated fertilizer compared to common fertilizers due to very less nutrient losses. Most common three marketed products are Nutricote, Osmocote and Polyon. Coatings are tough, resist to damage and thin. Nutrient release is due to controlled diffusion, which is fairly constant over time. Release depends on coat thickness, chemistry, temperature and moisture.Keywords
Polymer Coated Fertilizers, Advance Technique, Nutrient Management.References
- Dong, Y. and Wang, Z.Y. (2007). Release characteristics of different nitrogen forms in an uncoated and coated slow release fertilizers. Agric. Sci., 6(3): 330-337.
- Drost, D. and Koenig, R. (2002). Nitrogen use efficiency and onion yield increased with a polymer coated nitrogen source. Hort. Sci., 37(2): 338-342.
- Gordon, W.B. and Tindall, T. (2006). Fluid phosphorus performance improved with polymers. Fluid J., 12-13.
- Gordon, W. B. (2007). Improving the efficiency of phosphorus fertilizers. 2007 Indiana CCA Conference Proceedings. 1-13.
- Halvorson, A.D., Grosso, S.J.D. and Alluvione, F. (2009). Nitrogen rate and source effects on nitrous oxide emissions from irrigated cropping systems in Colorado. Better Crops, 93(1): 16-18.
- Halvorson, A.D. and Grosso, S.J.D. (2013). Nitrogen source and placement effects on soil nitrous oxide emissions from no-till corn. J. Environ. Qual., 40: 1349-1360.
- Malhi, S.S. and Lemke, L.L. (2013). Effectiveness of seed row-placed N with polymer-coated and NBPT-treated urea for canola and wheat. J. Plant Nutr., 36(14): 2205-2224.
- Mortvedt, J.J. (1994). Needs for controlled-availability micronutrient fertilizers. Fertilizer Res., 38: 213-221.
- Murphy, L. and Sanders, L. (2007). Improving nitrogen and phosphorus use efficiency with polymer technology. 2007 Indiana CCA Conference Proceedings. 1-13.
- Nelson, K.A., Nash, P.R., Motavalli, P.P. and Meinhardt, C.G. (2012). Effects of polymer-coated urea application ratios on wheat. Agron. J., 104(4): 1074-1084.
- Nyborg, M., Solberg, E. D. and Pauly, D. G. (1995). Coating of phosphorus fertilizers with polymers increases crop yield and fertilizer efficiency. Better Crops, 79(3): 8-9.
- Palmer, B., Murphy, L. and Sanders, L., Improving fertilizer phosphorus use efficiency with avail polymer technology. American J. Agric. Bio. Sci., 7(1): 330-337.
- Pawel, W. (2013). Effect of polymer seed coating with micronutrients on soybeans in South Eastern coastal plains. American J. Agric. Bio. Sci., 8(4): 302-308.
- Pawel, W. (2013). Infuence of seed coating with micronutrients on growth and yield of winter wheat in South-Eastern coastal plains. American J. Agric. Bio. Sci., 8(3): 230-238.
- Said, F.N.B., Yusop, M.K. and Oad, F.C. (2014). Nutrient uptake, pH changes and yield of rice under slow release sulfur-coated urea fertilizers. Australian J. Crop Sci., 8(10): 1359-1366.
- Subbarao, V., Kartheek, G. and Sirisha, D. (2013). Slow release of potash fertilizer through polymer coating. Internat. J. Appl. Sci. Engg., 11(1): 25-30.
- Tang, S.H., Yang, S.H., Chen, J.S., Xu, P.Z., Zhang, F.B. and Shao, Y. (2007). Studies on the mechanism of single basal application of controlled-release fertilizers for increasing yield of rice (Oryza sativa L.). Agric. Sci. China, 6(5): 586-596.
- Thomas, D., Landis, R. and Kasten, D. (2009). Using polymer-coated controlled-release fertilizers in the nursery and after out planting. Forest Nursery Notes, Winter 2009, 5-12 pp.
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- Co-Crystals:A Review of Recent Trends in Co Crystallization of BCS Class II Drugs
Abstract Views :450 |
PDF Views:0
Authors
Ramu Samineni
1,
Jithendra Chimakurthy
2,
K. Sumalatha
3,
G. Dharani
3,
J. Rachana
3,
K. Manasa
3,
P. Anitha
3
Affiliations
1 Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, AP-522213, IN
2 Department of Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, AP-522213, IN
3 Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati, AP-517102, IN
1 Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, AP-522213, IN
2 Department of Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, AP-522213, IN
3 Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati, AP-517102, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3117-3124Abstract
Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient are the major constraints during the development of new product. Various approaches have been used for enhancement of solubility of poorly aqueous soluble drugs, but success of these approaches depends on physical and chemical nature of molecules being developed. Co-crystallization of drug substances offers a great opportunity for the development of new drug products with superior physicochemical properties such as melting point, flow ability, solubility, stability, bioavailability and permeability, while preserving the pharmacological properties of the active pharmaceutical ingredient. Co-crystals are multi-component systems in which two components, an active pharmaceutical ingredient and a co-former were present in different stichiomentric ratios and bonded together with non-covalent interactions in the crystal lattice. This review article presents a systematic overview of pharmaceutical co-crystals. Differences between co-crystals with salts, solvates and hydrates are summarized along with the advantages of co-crystals with examples. The theoretical parameters underlying the selection of co-formers and screening of co-crystals have been summarized and different methods of co-crystal formation and evaluation have been explained.Keywords
Pharmaceutical Co-Crystals, Co-Crystallization, Solubility, Supramolecular Synthons.References
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- Optimization of Oxiconazole Topical Emulgel Formulation for the Treatment of Skin Infections
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Authors
B. Hemalatha
1,
T. Pavani Priya
1,
K. Manasa
1,
Ch. Greeshmika
1,
P. Kavya
1,
Shaik Sayeeda Sarah
1,
K. Padmalatha
2
Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 3 (2022), Pagination: 232-236Abstract
Emulgel is one of the promising topical drug delivery system for the delivery of hydrophobic drugs which overcome a variety of disadvantages of ointments and creams like greasiness as well as phase inversion. The aim of present work was to develop and evaluate Oxiconazole emulgel. Oxiconazole emulgel was prepared by using polymers like Carbopol 934 and HPMC K4M at different concentrations. Oxiconazole is a broad spectrum anti - fungal agent used in treat of various skin infections such as athlete’s foot, jock itch and ring worm. The prepared emulgels were evaluated in terms of physical appearance, measurement of pH, viscosity, spreadability, drug content and in vitro diffusion studies and skin irritation study. Formulation F1 containing carbapol 934 is considered as optimized formulation because it showed highest drug release i.e., 58.57% in 8 hrs.Keywords
Topical Drug Delivery, Emulgel, Oxiconazole, Carbapol 934, HPMC K4M, In Vitro Diffusion StudiesReferences
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